ICC comprises different morphological features and molecular subsets. Determinant factors, including C-reactive protein (CRP), immune infiltrating condition and pathological characteristics, such as multiple lesions, tumor budding and vascular invasion, have been proven to be highly associated with outcomes after resection ( 8- 11).Ĭomorbidities are chronic conditions that impact patients’ life quality, especially in long-term postoperative recovery. The management of comorbidities in cancer treatment is crucial to physicians. Recent studies have demonstrated the strong influence of comorbidities on survival after surgery in different kinds of solid neoplasms, including vulvar cancer, colorectal cancer and breast cancer ( 12- 14). The Charlson Comorbidity Index (CCI), first proposed in 1984 by reviewing hospital charts, managed to account for the influence of a patients’ comorbidity condition in longitudinal studies ( 15). Since age has been subsequently determined to be correlated with prognosis, Charlson et al. modified the scoring system with the addition of patients’ age in 1994. The age-adjusted CCI (ACCI) incorporates the age as a correction variable of the final score by adding 1 point for every decade over 40 years old ( 16).
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